The Master of Science in Entomology: Vector-Borne Disease Biology degree program is housed within the Cornell University Department of Entomology. This program is structured to cross-train students in the fundamentals of vector biology and public health. Over the course of 2 years, students complete required courses offered through the Department of Entomology (College of Agriculture and Life Sciences) and Master of Public Health program (College of Veterinary Medicine). Students also plan, conduct, analyze, and summarize a thesis research project based on field work conducted with regional public agency partners. The purpose of this guide is to share operational details of the NEVBD MS program with others, with the intention to support those who may start a similar program at their institution. Examples of core competency areas, course objectives, application process, summer internship, MS thesis process, timeline and evaluation materials are provided in this guide.