Between Dec. 23, 2024 and Jan. 3, 2025, eCommons staff will not be available to answer email and will not be able to provide DOIs until after Jan. 6. If you need a DOI for a dataset during this period, consider Dryad or OpenICPSR. If you need support submitting material before the winter break, please contact us by Thursday, Dec. 19 at noon. Thank you!
Library

eCommons

 

In Vitro Scaffold Construction for a Bio-artificial Liver

Simple item page
dc.contributor.authorWebster, Brad
dc.contributor.authorJong Kim, Tak
dc.contributor.authorChow, Sharon
dc.contributor.authorWang, Jeff
dc.contributor.authorTsai, Chrissy
dc.date.accessioned2004-06-17T21:22:03Z
dc.date.available2004-06-17T21:22:03Z
dc.date.issued2004-06-17T21:22:03Z
dc.description.abstractThe main focus of this investigation is to design a scaffold that will accommodate a growing Bio-Artificial Liver (BAL) with oxygen. The two design objectives are to find the maximum length and the distance between the artificial capillaries of the scaffold to provide adequate oxygen supply above 1.98 x 10-19 g/um3 to prevent hypoxia to the growing liver tissues. By utilizing industrial modeling software, FIDAP and GAMBIT, a model of a single capillary with liver tissue attached directly was constructed to simulate the oxygen delivery by means of diffusion and convection from the capillary wall to the tissue and the uptake by metabolism. From the results obtained, it was concluded that diffusion, not convection of the oxygen flow within the capillary was the dominant process of oxygen transport throughout the tissue. The maximum distance traveled into the tissue with capillary length of 60 ?m was 147 ?m from the capillary at the inlet side of the tissue while diffusion at the outlet tissue was at a modest 108 ?m. These values are unacceptable for the feasible construction of oxygen transport system solely based on diffusion. Thus, this investigation concludes that novel methods of greater complexity are needed to construct a more efficient and economically applicable oxygen delivery system for the mass production of bio-organs.en_US
dc.format.extent218273 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/1813/130
dc.language.isoen_US
dc.subjectliver, oxygen transport
dc.titleIn Vitro Scaffold Construction for a Bio-artificial Liveren_US
dc.typereporten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
balfinal .pdf
Size:
213.16 KB
Format:
Adobe Portable Document Format
Download

Collections

BEE 4530 - 2004 Student Papers