This report summarizes the results of water quality monitoring efforts related to Cornell University’s Lake Source Cooling (LSC) facility in 2010. This monitoring program began in 1998 and was performed annually by the Upstate Freshwater Institute (UFI) until 2006. In 2007 water sample collection and generation of the annual report was taken over by the DeFrees Hydraulics Laboratory of the School of Civil and Environmental Engineering at Cornell University. UFI continues to carry out all laboratory analysis. The format of this report is largely based on previous annual reports written by UFI.