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Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects

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dc.contributor.authorPetschenka, G.
dc.contributor.authorFei, C. S.
dc.contributor.authorAraya, J. J.
dc.contributor.authorSchröder, S.
dc.contributor.authorTimmermann, B. N.
dc.contributor.authorAgrawal, Anurag A.
dc.date.accessioned2019-08-02T13:06:53Z
dc.date.available2019-08-02T13:06:53Z
dc.date.issued2018-09-28
dc.description.abstractA major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive. The highly specialized monarch butterfly (Danaus plexippus) copes well with cardiac glycosides (inhibitors of animal Na+/K+-ATPases) from its milkweed host plants, but selective inhibition of its Na+/K+-ATPase by different compounds has not been previously tested. We applied 17 cardiac glycosides to the D. plexippus-Na+/K+-ATPase and to the more susceptible Na+/K+-ATPases of two non-adapted insects (Euploea core and Schistocerca gregaria). Structural features (e.g., sugar residues) predicted in vitro inhibitory activity and comparison of insect Na+/K+-ATPases revealed that the monarch has evolved a highly resistant enzyme overall. Nonetheless, we found evidence for relative selectivity of individual cardiac glycosides reaching from 4- to 94-fold differences of inhibition between non-adapted Na+/K+-ATPase and D. plexippus-Na+/K+-ATPase. This toxin receptor specificity suggests a mechanism how plants could target herbivores selectively and thus provides a strong basis for pairwise coevolutionary interactions between plants and herbivorous insects.
dc.identifier.urihttps://hdl.handle.net/1813/66771
dc.language.isoen_US
dc.publisherFrontiers Media
dc.relation.doihttps://doi.org/10.3389/fpls.2018.01424
dc.relation.hasversionPetschenka, G., Fei, C. S., Araya, J. J., Schröder, S., Timmermann, B. N., & Agrawal, A. A. (2018). Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects. Frontiers in Plant Science, 9
dc.relation.ispartofseriesFrontiers in Plant Science
dc.subjectmonarch butterfly
dc.subjectNaC/KC-ATPase
dc.subjectcardenolide
dc.subjectcardiac glycoside
dc.subjectphytochemical diversity
dc.subjectstructure–activity relationship
dc.subjecttoxin–receptor interaction
dc.subjectresistance
dc.titleRelative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects
dc.typearticle
dcterms.licensehttps://hdl.handle.net/1813/60291

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