Diagnosis, pathophysiology and treatment of glomerulopathy in a dog
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A nine-year-old, female spayed Norwegian Elkhound presented to Cornell University Hospital for Animals on 9/18/03 with a chief complaint of renal disease and anemia. Significant findings on physical examination and diagnostic workup included thin body condition, grade 2/6 systolic murmur, non-regenerative anemia, proteinuria, azotemia, hypoalbuminemia, hyperphosphatemia, hypertension as well as multiple splenic and a single hepatic nodule. These findings were consistent with a glomerulopathy, but without biopsy glomerulonephritis could not be distinguished from amyloidosis. Pathogenesis of glomerular disease in Inga's case may include Lyme nephritis, immune complex glomerulonephritis secondary to neoplasia, amyloidosis or another unidentified cause. Inga was treated with multiple supportive therapies such as enalapril, amlodipine, famotidine, subcutaneous fluids and Epogen. Despite initial improvement in quality of life, Inga deteriorated in mid-October 2003 and was euthanized by her referring veterinarian.
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Seminar SF610.1 2004 O85