Finding A Volume Ratio of Hyaluronic Acid to Phe-Arg-Poly(ester amide)s to Form Drug-Delivering Nanoparticle Micelles and Preliminary Drug Loading Result
Pseudo-protein is a name used to describe an amino acid based poly(ester amide)s (aa-PEA). One possible application of pseudo-protein is as a drug delivery coating.To form a drug-delivery micelle, positively charged Phenylalanine-Arginine-PEA (Phe-Arg-PEA) was mixed with negatively charged hyaluronic acid (HA). HA, a natural polysaccharide abundant in human skin and the extracellular matrix, binds to the CD44 glycoprotein receptor on surface of cancer cells and is therefore a possible pathway to the development of precisely targeted cancer treatments. Nanoparticle micelles with smaller diameters are more efficient in the drug delivery process. In this study we attempted to find and adjust the ratio of hyaluronic acid to Phe-Arg-PEA to form nanoparticles of optimized size. Preliminary data on drug loading capability of sample ratio 3:2 were also summarized.
Pseudo-protein; nanoparticle; Chemistry
Zax, David B.
Davis, Harry Floyd
Chemistry and Chemical Biology
M.S., Chemistry and Chemical Biology
Master of Science
dissertation or thesis