2019 CVM News: Salmonella Typhoid

Abstract

This news item from Cornell Research is about: Jeongmin Song, Microbiology and Immunology, is developing new approaches to treat typhoid fever. One such essential virulence factor specific to S. Typhi is a recently discovered toxin: typhoid toxin. Typhoid toxin has many unique structural and functional features. When administered to laboratory animals, typhoid toxin recapitulated many of the characteristic symptoms of typhoid fever, such as lethargy, malaise, stupor, leukopenia, and neurological complications. The researchers are finding that typhoid toxin play a similar role during human infection.