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MAGNETIC SUSCEPTIBILITY APPROACH FOR QUANTITATIVE CEREBRAL OXYGEN METABOLISM MAPPING

Author
Zhang, Jingwei
Abstract
Magnetic resonance imaging (MRI) is a noninvasive technique that allows imaging three dimensional volume through the body, providing superior soft tissue contrast compared to CT without ionizing radiation. MRI can be used to detect field inhomogeneity induced by blood iron molecules such as deoxyhemoglobin, methemoglobin, and hemosiderin, providing opportunities to identify and quantify these molecules and oxygen consumption, especially in brain. This dissertation reports: 1) a clinical study on intracranial hematoma evolution using quantitative susceptibility mapping (QSM); 2) a new magnetic susceptibility based signal model and MRI technique to quantitatively map cerebral metabolic rate of oxygen (CMRO2) and oxygen extraction fraction (OEF) using QSM; 3) a new algorithm to improve SNR of QSM-based CMRO2 using prior knowledge; 4) a new algorithm called minimal local variance (MLV) to improve clinical practicality of QSM-based CMRO2 by removing the requirement of blood flow challenge. The potential impacts, limitations and future directions of each studies are also discussed.
Date Issued
2017-05-30Subject
Quantitative Susceptibility Mapping; Biomedical engineering; Magnetic Resonance Imaging; Magnetic Susceptibility; Quantitative Cerebral Oxygen Metabolism Mapping
Committee Chair
Wang, Yi
Committee Member
Gupta, Ajay; Doerschuk, Peter C.
Degree Discipline
Biomedical Engineering
Degree Name
Ph. D., Biomedical Engineering
Degree Level
Doctor of Philosophy
Rights
Attribution-ShareAlike 4.0 International
Type
dissertation or thesis
Except where otherwise noted, this item's license is described as Attribution-ShareAlike 4.0 International