eCommons

 

CVM Research

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Research continues to be one of the major missions of the College of Veterinary Medicine at Cornell University. As such, its faculty, students, and research scientists produce materials such as posters and datasets that describe or are related to their basic, applied and translational research activities and accomplishments.

This collection includes research outputs that have been submitted voluntarily by faculty, postdoctoral fellows, graduate students, veterinary students, technical personnel, and other research associates. Open access is provided under Creative Commons licenses.

Further information about the College’s research activities can be found at http://www.vet.cornell.edu/research/

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Recent Submissions

Now showing 1 - 10 of 85
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    Surveillance Optimization Project for Chronic Wasting Disease dataset for Virginia, US, 2001- 2021
    Virginia Department of Wildlife Resources (2024)
    This dataset contains four files containing data from the Virginia Department of Wildlife Resources shared with the Cornell Wildlife Health Lab (CWHL) at Cornell University for the purpose of the Surveillance Optimization Project for Chronic Wasting Disease (SOP4CWD). Professionals at the source facility have provided written permission for professionals at the CWHL to post this open data to this persistent eCommons repository.
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    Data from: Evolutionary genomic analyses of canine E. coli infections identifies a relic capsular locus associated with resistance to multiple classes of antimicrobial drugs
    Ceres, Kristina; Zehr, Jordan D.; Murrell, Chloe; Millet, Jean K.; Sun, Qi; McQueary, Holly C.; Horton, Alanna; Cazer, Casey; Sams, Kelly; Reboul, Guillaume; Andreopoulos, William B.; Mitchell, Patrick K.; Anderson Renee; Franklin-Guild, Rebecca; Cronk, Brittany D.; Stanhope, Bryce J.; Burbick, Claire R.; Wolking, Rebecca; Peak, Laura; Zhang, Yan; McDowall, Rebeccah; Krishnamurthy, Aparna; Slavic, Durda; Sekhon, Prabhjot Kaur; Tyson, Gregory H.; Ceric, Olgica; Stanhope, Michael J.; Goodman, Laura B. (2024)
    These files contain data that support hypotheses presented in Ceres et. al. Evolutionary genomic analyses of canine E. coli infections identifies a relic capsular locus associated with resistance to multiple classes of antimicrobial drugs. In Ceres et. al. we found: Escherichia coli is the leading cause of death attributed to antimicrobial resistance (AMR) worldwide, and the known AMR mechanisms involve a range of functional proteins. Here we employed a pan-GWAS approach on over 1,000 E. coli isolates from sick dogs collected across the US and Canada and identified a strong statistical association of AMR, involving a range of antibiotics, to a group 1 capsular (CPS) gene cluster. This cluster included genes under relaxed selection pressure, had several loci missing, and pseudogenes for other key loci. It is widespread in E. coli and Klebsiella infections across multiple host species. Earlier studies demonstrated that the octameric CPS polysaccharide export protein Wza can transmit macrolide antibiotics into the E. coli periplasm. We suggest the CPS in question, and its highly divergent Wza, functions as an antibiotic trap, preventing drug penetration. We also highlight the high diversity of lineages circulating in dogs across all regions studied, overlap with human lineages, and regional prevalence of resistance to multiple drug classes.
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    Data from: Environmental and ecological signals predict periods of nutritional stress for Eastern Australian flying fox populations
    Eby, Peggy; Lagergren, John; Ruiz-Aravena, Manuel; Becker, Daniel J.; Madden, Wyatt; Ruytenberg, Lib; Hoegh, Andrew; Han, Barbara; Peel, Alison J.; Jacobson, Daniel; Plowright, Raina K. (2024-01-30)
    Food availability determines where animals use space across a landscape and therefore affects the risk of encounters that lead to zoonotic spillover. This relationship is evident in Australian flying foxes (Pteropus spp; fruit bats), where acute food shortages precede clusters of Hendra virus spillovers. Using explainable artificial intelligence, we predicted months of food shortages from climatological and ecological covariates (1996-2022) in eastern Australia. Overall accuracy in predicting months of low food availability on a test set from 2018 up to 2022 reached 93.33% and 92.59% based on climatological and bat-level features, respectively. Seasonality and Oceanic El Niño Index were the most important environmental features, while the number of bats in rescue centers and their body weights were the most important bat-level features. These models support predictive signals up to nine months in advance, facilitating action to mitigate spillover risk. This dataset supports this research and conclusions.
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    White Matter Atlas of the Domestic Canine Brain
    Inglis, Fiona M.; Taylor, Paul; Barry, Erica F.; Pascalau, Raluca; Voss, Henning; Johnson, Philippa J. (2024-01-23)
    These files contain a White Matter Atlas of the Domestic Canine Brain. This atlas is generated from diffusion tensor imaging and T1-weighted data collected from 30 mesaticephalic or dolicocephalic clinically and neurologically healthy canines. The final atlas includes a population average template generated from T1-weighted data, whole brain white matter priors created using manual segementation and white matter tracts generated from a population average diffusion dataset tractogram.
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    Data from: Low-dose sugammadex reverses moderate rocuronium-induced neuromuscular block in horses
    Martin-Flores, Manuel; Sakai, Daniel; Araos, Joaquin; Campoy, Luis (2024-01-19)
    These files contain data supporting all results reported in M Martin-Flores et al, EVJ-OA-23-200.R1 - Low-dose sugammadex reverses moderate rocuronium-induced neuromuscular block in horses. Fourteen adult horses undergoing different procedures were anesthetized with detomidine and isoflurane. All horses received NMB with rocuronium 0.3 mg/kg IV. Neuromuscular function was measured with acceleromyographic train-of-four (TOF) ratio. Recovery occurred spontaneously in five horses weighing [median (range)] 548 (413 – 594) kg and was enhanced with sugammadex 200 mg (total dose) in nine horses [433 (362 – 515)] kg. Recovery time from moderate NMB to a TOF ratio 1.0, and total duration of NMB were compared between groups. The dose of sugammadex was 0.46 (0.39 – 0.55) mg/kg. The recovery period lasted 21 (17 – 39) minutes for spontaneous and 4 (3 – 7) minutes for sugammadex. Total duration of NMB was 58 (41 – 70) minutes for spontaneous and 36 (21 – 43) for sugammadex (both p ≤ 0.003). There were no instances of recurarization.
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    Chronic Wasting Disease Surveillance Optimization Software (n x 2)
    Hanley, Brenda J.; Mitchell, Corey I.; Them, Cara E.; Walter, W. David; Walsh, Daniel P.,; Jennelle, Christopher S.; Hollingshead, Nicholas A.; Abbott, Rachel C.; Kelly, James D.; Grove, Daniel M.; Williams, David; Christensen, Sonja A.; Ahmed, Md Sohel; Booth, James G.; Guinness, Joseph; Gagne, Roderick B.; DiSalvo, Andrew R.; Fleegle, Jeannine T.; Rosenberry, Christopher S.; Miller, Landon A.; Schuler, Krysten L. (2023-09-22)
    The Chronic Wasting Disease Surveillance Optimization Software (n x 2) computes sampling recommendations for state, tribal, or provincial wildlife management agencies when the goal of the disease surveillance program is to detect chronic wasting disease (CWD) in white-tailed deer (Odocoileus virginianus). Driven by a combinatorial optimization algorithm, the Software pinpoints the number of surveillance points that should be evaluated in each county (or administrative area) to maximize the return-on-investment of sampling to the agency, while staying within the predetermined annual CWD surveillance budget. Agency representatives parameterize their Software with their total annual budget, weightings for specific management objectives, a summary of the historical sampling data, per-deer sampling costs, benefits of first and early detections, risk of spread, and benefits of an ad hoc sampling strategy. Outputs include the set of counties that should be sampled in the upcoming surveillance season. We designed the Software for use in Tennessee, US, but included directions for other states or provinces.
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    Surveillance Benefit Components for Chronic Wasting Disease in White-Tailed Deer
    Them, Cara E.; Mitchell, Corey I.; Hollingshead, Nicholas A.; Abbott, Rachel C.; Hanley, Brenda J.; Ahmed, Md Sohel; Booth, James G.; Jennelle, Chris S.; Hodel, Florian H.; Guinness, Joe; Ballard, Jennifer R.; Riggs, A. J.; Middaugh, Christopher R.; Cunningham, Mark; Clemons, Bambi; Sayler, Katherine; Killmaster, Charlie H.; Harms, Tyler M.; Ruden, Rachel M.; Caudell, Joe; Westrich, Michelle Benavidez; McCallen, Emily; Casey, Christine; O’Brien, Lindsey M.; Trudeau, Jonathan K.; Straka, Kelly; Stewart, Chad; Carstensen, Michelle; McKinley, William T.; Hynes, Kevin P.; Ableman, Ashley; Miller, Lauren A.; Cook, Merril; Myers, Ryan; Shaw, Jonathan; Van de Berg, Sarah; Tonkovich, Michael J.; Nituch, Larissa; Kelly, James D.; Grove, Daniel M.; Storm, Daniel J.; Schuler, Krysten L. (2023-09-22)
    The Surveillance Benefit Components for Chronic Wasting Disease in White-Tailed Deer is multivariable data representing epidemiological, population, ecological, and anthropogenic attributes of chronic wasting disease (CWD) in wild, white-tailed deer (Odocoileus virginianus) in the region of the United States (US) containing the states of Arkansas, Florida, Georgia, Indiana, Iowa, Kentucky, Maryland, Michigan, Minnesota, Mississippi, New York, North Carolina, Ohio, Tennessee, and Wisconsin, and in the region of Canada containing the province of Ontario. The data was made available through state and provincial wildlife agencies in partnership with the Surveillance Optimization Project for Chronic Wasting Disease (SOP4CWD), administered by the Cornell Wildlife Health Lab (CWHL) at Cornell University and Boone and Crockett Quantitative Wildlife Center at Michigan State University. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government.
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    Wildlife Disease Hazard Software Version 2
    Them, Cara E.; Hanley, Brenda J.; Mitchell, Corey I.; Abbott, Rachel C.; Hollingshead, Nicholas A.; Schuler, Krysten L. (2023-08-21)
    The Wildlife Disease Hazard Software Version 2 depicts US counties in which anthropogenic activities enhance the risk of CWD introduction and pinpoints how cervid demographic parameters influence the spread of CWD. We packaged the software using examples from the states of Tennessee and New York. We included for each example state the (redacted) hazard and (redacted) demographic data from white-tailed deer (Odocoileus virginianus). The software can be adapted for use in other geographical entities such as province or Tribal nation. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government.
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    Raptor Health V4: Software to assess the population-scale impact of mortality in raptors
    Hanley, Brenda; Dhondt, André; Forzán, María; Bunting, Elizabeth M.; Pokras, Mark A.; Hynes, Kevin P.; Dominquez-Villegas, Ernesto; Schuler, Krysten L. (2023-08-18)
    The Raptor Health V4 software allows wildlife professionals to use a mathematical model and 17-sequential years of nesting or breeding adult count data to examine the localized population-scale impacts to raptor populations arising from one or more source of observed mortality. The mathematical model is the closed-system Lefkovitch matrix, where closed-system is defined to be no gains or losses to the population from dispersal. The software allows the user to input demographic parameters as well as time series data (counts of nesting pairs and counts of mortalities) to produce comparative demographic quantities between a population with and without the source of mortality, including the annual and bi-annual abundances of hatchlings, non-breeders, and breeders, growth rates (long-term, transient, cumulative, and stochastic), stable stage distributions, reproductive values, and dominant elasticities. The software automatically generates non-parametric (Kruskal-Wallis) statistical tests to compare differences in median growth rates between populations with and without the source of mortality, as well as quantifies the bias introduced through the use of the algorithm as an estimator. Default values in the software depict parameters of bald eagles (Haliaeetus leucocephalus) and eagle nesting and mortality data collected by biologists at the New York State Department of Environmental Conservation (NYSDEC).
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    Habitat Risk Version 2 Software
    Hanley, Brenda; Mitchell, Corey I.; Walter, W. David; Them, Cara E.; Kelly, James D.; Abbott, Rachel C.; Hollingshead, Nicholas A.; Miller, Landon A.; Schuler, Krysten L. (2023-08-18)
    The Habitat Risk Version 2 Software, hereafter “Habitat Risk V2”, leverages a previously published Bayesian hierarchical model framework with opportunistic (hunter-harvest) wildlife surveillance disease testing data and publicly available geospatial (raster) data to estimate the geographical risk that a hunter will harvest a white-tailed deer (Odocoileus virginianus) that tests positive for chronic wasting disease (CWD) in a small “study area” portion of the state. The three-part R scripts of Habitat Risk V2: 1) prepare the surveillance (testing) and geospatial (raster) data for model inclusion, 2) parameterize and estimate coefficient values for twenty five predetermined candidate model structures (Table 1), 3) select the model structure with the lowest Deviance Information Criterion (DIC) given the data, 4) gather diagnostic plots for the user to verify modeling assumptions have been met, and then 5) display the results of the best model in geographical and tabular context via an interactive user interface (UI). UI capabilities include interactive and downloadable maps of estimated risk (and associated error), a map of disease data overlaid onto spatial covariates, and detailed statistical information about the best model and the model selection process. The three R scripts must be run in sequence, as the data outputs of one become the data inputs of the next. The Habitat Risk V2 requires testing data in the state of interest to 1) contain locations of each deer in exact latitude/longitude coordinates, and 2) contain least one record that is CWD positive for each age/sex segment (adult male, adult female, yearling male, yearling female, fawn male, fawn female). The software will not work on datasets containing all CWD negative deer. We packaged Habitat Risk V2 using examples from Tennessee and New York. This packet does not furnish the real disease testing data necessary to run Habitat Risk V2. The Habitat Risk V2 software is adaptable for use in other areas with positive CWD samples. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the United States Government.