Renal Tissue Preservation: Cooling the human kidney for optimal transport conditions
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Calve, Sarah; Gartenberg, Shaun; Taxier, Karen; Utz, Edward
End Stage Renal Disease affects over 80,000 Americans each year. While there is no known cure, kidney transplants are the most effective way to combat the disease while bettering the quality of life for the patient. In this study, we implemented computer aided engineering in order to determine how a kidney cools during the time between harvest and transplantation. Our goal was to sustain the organ as long as possible outside the body while controlling for temperature and oxygen supply. We found that oxygen concentration of the kidney is only dependent on the boundary condition placed on the oxygen, and not at all related to the cooling rate. Our results showed that perfusion is beneficial because it is able to maintain the necessary amount of oxygen required for the kidney to sustain its own metabolism.
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