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College of Arts and Sciences Honors Theses
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The use of reverse line-blot hybridization for the detection of Trichostrongylid nematodes in small ruminants
Giorgio, Rachel (2018-05)Helminth infections are among the top causes of economic loss in the upkeep of small ruminants, and with anthelmintic resistance on the rise, it is vital that rapid and versatile diagnostic tests be developed to better ... -
Approximate Bayesian Computation for Studying Selective Sweep Signatures in Local Coalescence Trees
Andrew Marderstein (2017-05)Understanding the process of rapid molecular adaptation is important for many key challenges humanity faces today, such as the evolution of pesticide and drug resistance. Our standard population genetic model for describing ... -
The Role of the Ventral Hippocampus and Anterior Olfactory Nucleus in Contextually Cued Odor Discrimination
Joshua Dobbin (2017-05)The hippocampus has been shown to play a crucial part in context encoding in rodents. However, the mechanisms by which the hippocampus affects contextually cued behavior have yet to be fully elucidated. In this study, I ... -
Population Scale Transcriptome Profiling from Mixed Samples using Single-Cell Analysis
Destini Gibbs (2017-05)One powerfull tool in understanding how genetic variations can lead to changes in gene expression across human population involves measuring mRNA expression levels in large scale, with high-throughput sequencing. Still, ... -
Mutagenesis of a conserved cysteine in the Hsp70 molecular chaperone BiP: Impact of amino acid substitution on BiP’s ability to protect cells against endoplasmic reticulumderived oxidative stress
Xu, Mengni (2015-01)Recently, it has been shown that oxidative protein folding in the endoplasmic reticulum (ER) produces potentially significant amounts of cellular reactive oxygen species (ROS). Although ROS accumulation can cause profound ...