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Bone marrow hypoplasia following fenbendazole administration in an 8 year old dog

Author
Brown, Megan
Abstract
An 8-year-old, male castrated Labrador Retriever presented with coughing, inappetence, lethargy and fever. Two days prior to presentation, one dose of fenbendazole had been given for chronic, intermittent diarrhea. Routine hemogram showed a severe neutropenia and moderate thrombocytopenia, while bone marrow aspirate cytology revealed bone marrow hypoplasia. Supportive care, including fluid therapy initially and broad-spectrum antibiotics for several weeks, resulted in complete resolution of clinical signs and hematologic abnormalities. An adverse drug reaction to fenbendazole was suspected based on the absence of detectable infectious and neoplastic causes as well as resolution of hematologic abnormalities following drug withdrawal.
Journal/Series
Senior seminar paper Seminar SF610.1 2011
Date Issued
2011-02-23Subject
Dogs -- Diseases -- Treatment -- Case studies; Dogs -- Effect of drugs on -- Case studies
Type
term paper