A 6.5-month-old Asian small clawed otter presented to the veterinary staff at the Cleveland Metroparks Zoo with a chief complaint of trauma. She had a single, large, circumferential laceration on the right antebrachium, as well as numerous puncture wounds and lacerations covering the paw. Radiographs showed several fractures in the phalanges and metacarpal bones, as well as a medial luxation of the elbow. Due to extensive tissue damage, complexity of orthopedic repair, and subsequent medical management that would be required, amputation was performed. The amount of soft tissue damage necessitated amputation of the mid-diaphyseal region on the radius and ulna in order to allow adequate closure of the wound. The otter received oral antibiotics and analgesics and was returned to her exhibit after one week of hospitalization. While this situation may seem comparatively easy to manage in domestic species, management in zoo species often presents some unique concerns and challenges.