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Presumptive paraneoplastic syndrome in a Dalmatian

Author
Prosser, Jeremy
Abstract
This paper discusses the case of a 9 year old, spayed, female Dalmatian who
presented with clinical signs consistent with lower motor neuron disease and was
diagnosed with presumptive paraneoplastic syndrome secondary to insulinoma. The
lower motor neuron clinical signs consisted of moderate to severe, generalized muscle
wasting and rapidly progressive generalized weakness over the course of one month.
Neurological examination revealed a short-strided gait in all four limbs, tetraparesis,
decreased withdrawal reflexes in all four limbs, and collapse if forced to walk without
assistance. The clinical signs and examination findings localized the lesion to the
neuromuscular system. Initial labwork revealed a hypoglycemia (blood glucose 36
mg/dL), with the remainder of the bloodwork relatively unremarkable. An insulin level
was performed, which revealed elevated levels over 200 uIU/mL (ref. 5-20). The clinical
signs of lower motor neuron disease were presumptively due to a paraneoplastic
syndrome secondary to the insulinoma, as other causes were not definitively ruled out
with muscle/nerve biopsies.
Journal/Series
Senior seminar paper Seminar SF610.1 2009 P76
Date Issued
2009-04-22Subject
Dogs -- Diseases -- Case studies
Type
term paper