A 1 year old intact female Black Labrador Retriever presented for evaluation of a fever of unknown origin (105.5oF), generalized stiffness of gait, cervical rigidity/pain, hyperesthesia of the spine, lethargy and inappetance. Prior to initial presentation, corticosteroid therapy had been initiated and resulted in the resolution of all clinical signs. A Complete Blood Count (CBC), cerebrospinal fluid analysis with culture and sensitivity, joint taps in conjunction with the responsiveness to corticosteroid therapy lead to a diagnosis of Steroid-Responsive Meningitis. Medical therapy was initiated to initially decrease the patient's fever and to control the clinical signs associated with Steroid-Responsive Meningitis. Tapering doses of corticosteroid therapy over the course of 6 months was recommended in order to prevent relapse with concurrent complete blood counts and CSF taps every 4-6 weeks to monitor the success of the therapy.