Electrospun nanofibers possess desirable properties as membrane materials for water and wastewater treatment. These attributes include a vast specific surface area, a structurally porous composition, and the ability to customize surface functionality. In this study, we present the development of a durable and insoluble nanofibrous web composed of poly-cyclodextrin (poly- CD) through electrospinning, utilizing Hydroxypropyl-β-Cyclodextrin (HPβCD) and a crosslinking agent 1,2,3,4-Butanetetracarboxylic acid (BTCA). The poly-CD webs exhibit stable fiber morphology, insolubility in both water and organic solvents, and highly hydrophilic nature, making them an ideal material for filtration applications. The composition and thermal analysis confirm the formation and existence of cross-linked poly-CD nanofiber structures. Remarkably, the poly-CD nanofibrous webs show superior removal performance of various types of organic micropollutants, including triclosan (antibacterial agent), ciprofloxacin (drug molecule), and oxybenzone (personal care product). Furthermore, the poly-CD nanofibers are easily regenerated through a simple washing procedure, displaying successful reusability. Additionally, the poly-CD web exhibits excellent adsorption capacity for all of the three types of organic micropollutants tested. The utilization of poly-CD nanofibers, derived from bio-renewable sources like starch, presents a sustainable and promising approach for addressing organic micropollutant contamination in water. Our findings demonstrate that the poly-CD nanofibrous membrane is a promising solution for efficient filtration of organic micropollutants from aqueous environments.