Proposition 65, also known as the Safe Drinking Water and Toxic Enforcement Act, is a California law that mandates businesses to inform consumers of significant exposure to chemicals that are known to cause cancer, birth defects, or reproductive harm. It has been claimed as one of the most controversial regulations which has gained more attentive momentum in food industry due to numbers of profound case lawsuits. The purpose of this study is to conduct a comprehensive analysis of the food contaminant legislation, evaluate its effectiveness and criticized undue burdensome evolved food industry, and assess the opinions of the U.S. consumer public towards similar regulations being implemented nationally, as well as how their perceptions impact purchase decisions. The survey questionnaire was developed based on demographic characteristics from U.S. Census to collect the data from 305 respondents. A large number (87.8%) of participants in this study regardless of demographic factors (gender, age, race, education, and household income) shared the strong aspirations on the adoption of Prop 65-alike regulations in other states or nationwide. Education levels and household incomes were found to be two key factors significantly affecting and associating (p-value <0.05) with greater knowledge and awareness of existing Prop 65 legislation, consumer behaviors, and purchase decision influences.