This article outlines the parallels between feline infectious peritonitis (FIP) and COVID-19. The effect of SARS-Cov-2 on the human vascular system are only starting to be understood. From cardiac complications and COVID toes in adults, to multisystem inflammatory syndrome in children (MIS-C), the world of human medicine is tackling some of the more perplexing and severe complications of SARS-2 in real time. Dr. Alison Stout and her colleagues at the Whittaker Lab share insights learned from years studying FIP and make a compelling argument for a one-health approach to the global pandemic.