Topics in this Annual Report include: A Commitment to Excellence [Letter from the Program Director]; Acknowledgements; Contents; 2005 Leadership Program Agenda; 2005 Leadership Program Participants; Activities 2005: Research, Leadership, Leadership in Action, Emerging Diseases, Biodefense and Public Health, Drug Design, Career Explorations, Graduate Training; Cornell's Partnership with the National Institutes of Health: Topics and Speakers; The USDA and Animal Agriculture: Topics and Speakers; Presentations and Prizes; Program Fellows and Their Research 2005; Counselors and Facilitators for the 2005 Leadership Program; Housing; Program Coordinator; Program Dinner; Time Out; Where Are They Now?; Reunion 2005; What Did They Say?; In the Limelight: Emma J. O'Neill