This report examined energy recovery in the context of a centralized dairy bio-energy system. The system consists of a series of anaerobic digestion (AD) and hydrothermal liquefaction (HTL) processes to treat dairy manure from New York State farms. The centralization of such an energy system was evaluated using geographic information systems. The spatial analysis showed that centralization was key in optimizing transportation logistics and benefiting from economies of scale. The feasibility of the bioenergy system was assessed by performing a techno-economic analysis. It has been shown that the feasibility depends on many factors, with system scale being the most determinant factor. The integrated AD/HTL system diversifies the bio-product slate, expanding the revenue streams. Other variables such as electricity selling price and government support in forms of tax incentives and subsidies also greatly impact the economics of the project.