'I've Got the Life,' a six year old Standardbred mare, was a successful trotter that was due to foal in early March 2007 when the manager noticed premature udder development at day 304 of gestation. The referring veterinarian (rDVM) promptly began treatment for suspected placentitis and referred her to Cornell University's Equine and Farm Animal Hospital for high-risk management of the pregnancy. On presenation, I've Got the Life was quiet, alert, and responsive. The physical examination revealed significant udder development, but was otherwise unremarkable. Bloodwork revealed an elevated fibrinogen, which was indicative of inflammation. Trans-abdominal ultrasound was performed and revealed an increased uteroplacental thickness (CTUP) of 1.6cm. I've Got the Life was treated with antibiotics, anti-inflammatories, progesterone, and vitamin E. She maintained the pregnancy until day 330, when she foaled a mature and healthy filly. This paper will focus on the pathophysiology, diagnosis, and treatment fo placentitis in the mare.