IN THIS ISSUE: Editorial /2 ... Preventing Blackouts /3 (The control of large-scale electric power systems is discussed by James S. Thorp, professor of electrical engineering, who is applying the relatively new concept of guaranteed stability to problems of emergency response in massive power grids.) ... How Control Theory Improves Cancer Therapy /10 (The success of chemotherapy in controlling cancer depends on optimal treatment regimes that destroy or inhibit malignant cells with the least possible effect on normal cells. Research in the area of cell kinetics is discussed by Myunghwan Kim, professor of electrical engineering.) ... Controlling Weevils and Worms: The Use of Optimization Methods in Pest Management /17 (Mathematical modeling and optimization are being used to determine the best control strategies for crops threatened by pests. Christine A. Shoemaker, associate professor, and Jery R. Stedinger, assistant professor of civil and environmental engineering, describe their research.) ... The Beautiful Simplicity of Feedback Control /26 (Physical understanding combined with mathematical analysis makes control theory readily applicable to real-world problems. A theory based on this approach is explained by Richard M. Phelan, professor of mechanical and aerospace engineering.) ... Vantage /36 (Our photographers cover fall events, including the dedication of the Joseph N. Pew, Jr., Engineering Quadrangle, and the key participation of engineers in Big Red athletics.) ... Register /42 ... Faculty Publications /47 ... Letters /52