A thirteen year old female spayed standard poodle presented for unilateral epistaxis and weakness. Bloodwork confirmed the presence of a hyperproteinemia characterized by a hyperglobulinemia and hypoalbuminemia. Serum electrophoresis and immunoglobulin quantification revealed a monoclonal gammopathy of immunoglobulin G. Plasmacytosis of the bone marrow was diagnosed based on examination of bone marrow aspiration cytology. A diagnosis of multiple myeloma was made and the patient was given a fair prognosis with a median survival time of one and a half years with appropriate therapy.