Urbanization and industrialization have caused a sharp growth in solid waste generation and accumulation globally, which imposes a severe burden on the environment. Industrial Solid Waste (ISW), as an essential part of solid waste, has not gotten enough attention for a long time. The paper analyzes the driving forces of ISW generation in China using the Environmental Kuznets Curve (EKC) framework. Based on panel data of 140 cities in China from 2006 to 2015, the study examined the existence of an EKC relationship between per capita income and the generation of ISW. Our results show that the relationship between income level and ISW generation per capita, as the pollution indicator, presents an inverse U-shape, confirming the EKC hypothesis. Only a few cities in China have attained the turning point income level. Therefore, in most Chinese cities, the ISW generation is now increasing with the economic growth. After performing the heterogeneity analysis, we also found that the peak ISW pollution level of the cities would increase with the augment of the proportion of second industry to GDP industrial and the volume of freight of city.