"Benito", a 6 year old castrated male ferret, presented to the Cornell University Hospital for Animals' Exotics Service for suspected granular lymphoma and severe peripheral lymphadenopathy. Benito's problem list included: generalized peripheral lymphadenopathy; presence of multiple masses within the abdomen and retroperitonealy; splenomegaly; diminished heart and lung sounds; tachypnea; possible hepatomegaly; possible right adrenal enlargement; tail alopecia; lethargy; inappetance; and hind end weakness. The primary differential diagnosis for these problems was lymphoma. Results of a Complete Blood Count, Chemistry Panel, orthogonal whole body radiographs, abdominal ultrasound, splenic aspirate, and lymph node biopsy were consistent with a diagnosis of Stage Vb, biologically high grade (histologically intermediate grade), multicentric granular lymphoma, likely of T-cell or Natural Killer cell origin. Prior to initiation of treatment with chemotherapy, Benito died at home. This paper discusses Benito's case and lymphoma in ferrets in general. Classification of lymphoma in ferrets and treatment options are also explored.