A two-and-a-half year old male castrated, mixed breed dog presented with severe ulcerative lesions affecting primarily both ear pinnae, the oral cavity, and all four foot pads. Despite repeated attempts to ameliorate the animal's condition, it progressively worsened over time and was refractory to medical therapy. Considering biopsy features in conjunction with the widespread distribution of lesions and overall clinical presentation, a presumptive diagnosis of Epidermolysis Bullosa Acquisita (EBA) was made. Treatment consisted of a multi-drug regimen including glucocorticoids, antibiotics, colchicine, antiinflammatories, and pain management. However, remission was not achieved and life-long medical management may be warranted.