Gastric squamous cell carcinoma (GSCC) was diagnosed in a 9 year old gelding zebra horse cross. This gelding had GSCC with both local extension and metastasis into the liver, hepatic lymph node, spleen, omentum, diaphragm, and lungs. Lymphatic and hematogenous metastases are not uncommon for this tumor type as well as carcinomatosis. Gastric neoplasia accounts for about 1.5% of all neoplasms in horses. Squamous cell carcinoma is the most common type of gastric neoplasia but only represents about 3-4% for squamous cell carcinomas in horses.[1-3] GSCC has not been reported in zebras or zebra horse crosses.