Managing the coexistence of commodity crops within supply chains and global food presents challenges. For biotechnology to fully realize the benefit of increased global food security, its products must be effectively integrated into the global food system. However, many international challenges exist in balancing innovation with market access, including asynchronous approvals and zero tolerance for approved GE traits. Governments, with the assistance of independent scientific groups, are in the best position to provide cogent policies that assure both industries and consumers.