Pollinators, especially bees, play a pivotal role in agriculture, crop pollination, and global food security. However, their populations are being threatened by factors such as pesticide exposure, climate change, and pathogens. Neonicotinoids are insecticides that have been vastly demonstrated to be harmful to non-target organisms such as bees and aquatic life. They are especially problematic since they are water soluble and can infiltrate plant products that are foraged by bees. This dissertation describes the synthesis, characterization, and evaluation of ingestible hydrogel microparticles (IHMs) with the purpose of detoxifying neonicotinoid insecticides and improving bee health post-exposure. First, IHMs were synthesized using a straight-forward precipitation polymerization approach and they were confirmed to adsorb three neonicotinoids, imidacloprid, clothianidin, and thiamethoxam, in vitro. The biodistribution and ability of IHMs to travel through the gastrointestinal tract were confirmed as well using fluorescence microscopy. Exposure to lethal concentrations of neonicotinoids were then used as a metric to assess IHM efficacy in reducing mortality in bumblebees (Bombus impatiens). Next, the ability to address sublethal effects was investigated. In addition to effects on mortality, neonicotinoids have also been shown to invoke neurological and mitochondrial damage and oxidative stress that can manifest as declines in physiological and learning performance. For sublethal assessments, bumblebees were individually provided a sublethal dose of imidacloprid, thus ensuring consistency in exposure that allowed for in-depth comparisons between experimental groups. Relative to bees only given an imidacloprid dose and plain sucrose syrup, bees receiving IHM treatment experienced improvements in vital physiological parameters such as syrup consumption, wingbeat frequency, and locomotor activity, indicating improvements in their health and performance. In all experiments, bees without IHM treatment exhibited substantial decreases in performance after imidacloprid dosing which highlights just how toxic imidacloprid is. Finally, a discussion of future work for addressing the issue of pesticide toxicity in bees is presented. This research underscores the urgent need for sustainable solutions to mitigate pesticide-induced harm to bee populations. In addition, the methodology presented can be implemented in future studies that aim to assess the efficacy of biomaterial-based strategies in alleviating the harmful effects of pesticides on bee health. Safeguarding these vital pollinators will aid in ensuring continued crop production and global food security.