An 11 year old male castrated Shetland Sheepdog was presented to the Cornell University Hospital for Animals for a recently detected prostatomegaly and a one year history of progressive lethargy, inappetence, stranguria, pollakiuria, and tenesmus with thin soft feces. Major physical examination findings included a dull but responsive mentation, a thin body condition, tachycardia (200 beats per minute), tacky oral mucous membranes, a fever (103.8 °F), a grade III/VI left-sided systolic heart murmur, prostatomegaly, and large feet with nonpainful, thickened bones palpated distally in all 4 limbs as well as decreased carpal and tarsal flexion and extension. A complete blood count, chemistry, abdominal ultrasound, prostatic fine needle aspirate, and free catch urine were performed, and the patient was diagnosed with a prostatic transitional cell carcinoma. The dog was euthanized and post-mortem carpal radiographs confirmed the presence of hypertrophic osteopathy.