Clay is a material with less embodied energy and more thermal benefits than otherconstruction materials. Maintaining indoor thermal comfort contributes to energy efficiency and healthy indoor air environment. Building Energy Simulations (BES) and nonstandard 3D fabrication techniques are key drivers for testing and designing sustainable architectural systems. However, we often see a dissociation between these two research pipelines, resulting in design iterations that lack performance evaluations. This research introduces an integrated workflow to design a lattice structured clay-printed brick system informed by environmental parameters including airflow and heat transfer performance. To articulate this environmentally performing clay brick system, this research leverages Computational Fluid Dynamics (CFD) and heat transfer analysis. Then, the research utilizes additive manufacturing technologies using the customized toolpath for fabricating complex brick geometries informed by environmental parameters. Lastly, the research delivers the possible architectural application in a specific climate condition to control the environmental factors, including airflow and daylight, and the domestic parameter such as privacy.