Digbee, a seven year old male, castrated Shih tzu presented to the Cornell Dermatology Service with a progressive history of crusted, pruritic, ulcerative lesions on mucocutaneous junctions. Clinical diagnostics consisted of a CBC/Chemistry Panel, bile acid assay. urinalysis, ultrasound and skin biopsies. The histopathology of the skin biopsies were pathogneumonic for Necrolytic Migratory Erythema. Introduction/Case History: Digbee is a seven year old, male castrated, 14.5 lb. Shih tzu that presented to the Cornell University Dermatology Service on 6/16/2002 for pruritic, crusting, ulcerative dermatosis of the footpads, ventral abdomen and external genitalia. Three months before presentation at Cornell, Digbee's paws became severely erythematous and pruritic. One month previous to presentation Digbee's paws progressed to erosion, ulceration and crusting making it difficult for him to walk. The lesions then spread to his prepuce and anus. The crusting around his prepuce and anus caused obstructive stranguria and tenesmus. The referring veterinarian prescribed an antihistamine with no noticeable improvement. Digbee was then prescribed a course of methylprednisolone and Baytril with some improvement noted in terms of comfort level. However, after the course of steroids was completed, Digbee relapsed to not walking and was placed back on steroids and antibiotics but with no noticeable improvement. The rDVM performed a complete blood cell count and chemistry panel, which revealed a mild hyperglycemia and increases in alkaline phosphatase and alanine transferase. Two days previous to presentation at Cornell, the owner noticed small, multifocal lesions on the ventrum and occassional whole body tremors at which time he was referred to Cornell with a tentative diagnosis of pemphigus foliaceous.