A 2-year-old female spayed Pug dog weighing 6.7 kg presented for ingestion of approximately 30 ibuprofen tablets (1,052 mg/kg). The patient began vomiting shortly after ingestion, and presented to our Emergency Service within 4-6 hours of consumption. Initial physical examination and point-of-care assessments were unremarkable. The patient was managed in hospital for 10 days and treated medically for Non-Steroidal Anti-inflammatory Drug (NSAID) toxicity. Notable abnormalities included azotemia, severe metabolic acidosis and severe anemia. During hospitalization, the patient developed Acute Kidney Injury (AKI) and gastrointestinal hemorrhage secondary to ibuprofen toxicity. This seminar will concentrate on the pathophysiology and treatment of Acute Kidney Injury and NSAID toxicity, as well as treatments specific to this patient.