Ocular disease is extremely common in cattle of all ages, the most common cause of which is infectious bovine keratoconjunctivitis, commonly known as pinkeye. It is most commonly caused by ocular infection with the bacterium Moraxella bovis. If left untreated, it can progress from a superficial corneal ulcer to perforation of the cornea. Perforation of the cornea may result in formation of a self-seal, with fibrin or iris filling in the corneal defect. Healing occurs by second intention, with excess granulation and scar tissue developing over the cornea. If glaucoma develops secondary to the abnormal healing of the eye, then the eye will appear grossly enlarged and will be painful to the animal. At this point, enucleation is the best option for continued comfort.