Despite universal acknowledgement of the pervasiveness of sex trafficking from Cambodia, lack of consensus and reliable, objective research on its mitigation from the abduction stage indirectly perpetuates its existence. This paper seeks to triangulate the drivers of sex trafficking from a systems-based approach to construct a human-centric pragmatic proposal to guide its mitigation and aid sustainable development efforts. Given that many present implementations are influenced by foreign agencies, ethical change frameworks were analyzed to formulate a methodology for ethical theory of change construction. The proposed multiphasic theory of change recognizes current barriers to propose an internal program model to elevate its practical deliverability with a focus on the Education-For-Education Model and a Design Monitoring Framework, which provides actionable insights to operationalize its implementation.