Two horses presented to the Cornell University Hospital for Animals for evaluation of a right forelimb lameness and an oro-sinus fistual, respectively. Both underwent elective general anesthesia. Upon recovery from anesthesia, both horses were acutely lame in the left forelimb which was diagnosed as post-anesthetic myopathy/neuropathy. Treatment was prompt and aggressive and both horses fully recovered. This paper will discuss potential causes, clinical signs, and treatment of post-anesthetic myopathy/neuropathy, as well as prevention.