In the United States, New York is the second largest apple producing state, generating an average of 29.5 million bushels each year. However, New York is also home to fire blight, a bacterial disease caused by the bacterium Erwinia amylovora. This disease can cause economic devastation and destroy entire plantings in a single growing season when environmental conditions favor disease development. The estimated annual losses due to fire blight, including management costs, have been estimated at over $100M USD. Fire blight management is further complicated by the presence of antibiotic-resistant populations of E. amylovora. As a graduate student, I conducted in vitro and field trials to determine the ways in which fire blight management can be optimized, and how new technologies incorporating UV-C can be implemented to best serve management efforts. We found field applications of UV-C at 200 J/m2 to be as effective at managing shoot blight as streptomycin, the leading antibiotic for fire blight management, and Aureobasidium pullulans, the leading biological for fire blight management. This finding is incredibly relevant as it provides an additional management practice for E. amylovora, capable of effectively managing bacterial populations with antibiotic resistance. We also determined the potential of UV-C applications to manage apple pests through in vitro studies with Aphis spiraecola where we found that UV-C exposure of 400 J/m2 significantly increased mortality and significantly decreased life stage advancement and fecundity across life stages. By evaluating 10 pruning programs in two orchards across two years, it was found that though pruning can be effective at managing disease in both high-density, and vertical-axis orchards, it has the greatest impact on disease management in larger trees grown in vertical-axis plantings. This finding is important as most modern orchards being planted are high-density. Given these results, it may be most efficient, in terms of time, labor, and cost, for the grower to remove and replant infected trees in high-density plantings. The research described in this dissertation contributes to our understanding of fire blight and sustainable disease management through the evaluation of new and existing management practices.