Information about residents of institutional and noninstitutional group quarters (GQ), particularly those with disabilities, has been limited by gaps in survey data, and statistics based on data that exclude some or all GQ residents are biased as estimates of total population statistics. We used the 2006 and 2007 American Community Survey (ACS) to identify the distribution of working-age populations with and without disabilities by major residence type, and to assess the sensitivity of disability statistics to GQ residence. Our findings showed that (1) of those with disabilities, about one in 13 males and one in 33 females live in GQ; (2) younger males with disabilities are more likely to reside there, particularly at institutional GQ; (3) individuals with and without disabilities who are black, American Indian, never married, or have less than a high school education had higher GQ residence rates; (4) 40% of male and 62% of female GQ residents have a disability; (5) adding GQ residents to household residents increases estimated disability prevalence for males by 6% and the estimated difference between disability prevalence rates by gender nearly disappears; and (6) inclusion of the GQ population substantively lowers employment rate estimates for males with disabilities—especially young blacks and American Indians.