The following case report describes the presentation, diagnostic workup, and treatment of a one and half year old female spayed Rottweiler who presented to the Orthopedic Surgery Service at the Cornell University Hospital for Animals for a presumptive diagnosis of left sided cranial cruciate ligament tear. Following a tibial wedge ostectomy and subsequently the placement of a modified Type II external fixator, a methicillin-resistant Staphylococcus intermedius (MRSI) infection formed at the surgical site. This seminar will discuss the background of methicillin-resistant Staphylococcus infections, clinical presentation of these infections, risk factors for developing such infections, and diagnostic and treatment options for these infections. Additionally, the relevance for zoonotic potential and reverse zoonotic potential will be discussed.