A 12 year-old Clydesdale gelding presented to the Cornell University Equine Hospital in November 2012, with a one-year history of recurrent, shifting lameness of the hind limbs. On arrival, the patient was a grade 2/5 lame on the left hind limb at the walk and was observed treading and biting at his distal limbs while standing in his stall. On palpation, all four limbs appeared to be affected in the same manner: severe diffuse thickening of the distal limbs, with a corrugated appearance of the skin from the tarsus or carpus down, with painful areas of crusting. Given the signalment and characteristic firm, nodular appearance of the distal limbs, Chronic Progressive Lymphedema (CPL) was strongly suspected. CPL is a devastating condition prevalent in several draft breeds including Shires, Clydesdales, and Belgian Draft horses. There is no definitive cure but progression can be slowed with careful management of hygiene, secondary infections and exercise.