The primary purpose of this graduate project is to share and discuss the benefits of entheogenic psychoactive fungi for common mental health challenges that significantly burden public health. The secondary aim is to develop food-based formulations of a single species of fungi from the genus Psilocybe for clinical therapeutic use and non-clinical use. These high-dose formulations were designed for both inpatient and outpatient settings for use under clinical supervision or as an adjunctive treatment for drug-resistant mood disorders. The full-dose formulations could be used in clinical settings to help treat mild to severe depression or a range of anxiety disorders. Use of these products should involve guidance and facilitation by a trained practitioner during an extended psychotherapy session, in an inpatient, or in an outpatient setting based on the client's needs, followed by integrative counseling. In addition to the full-dose formulations, other food-based options were developed at sub-perceptual dosages for use in a self-directed manner in a non-clinical setting. These food product formulations aim to enhance cognitive functioning, focus, mood, or creativity.