Exocrine carcinomas are the most common tumor of the feline exocrine pancreas, and they may arise from either the ductal or acinar cells of the exocrine pancreas. They are typically found in older cats, which present for abdominal pain, weight loss, anorexia and vomiting. Pancreatic exocrine carcinomas are typically aggressive and metastasize most commonly to the liver, regional lymph nodes or peritoneum. Treatment options typically are limited to surgery and palliative care. Prognosis for survival is grave, but individual exceptions exist.