A biotech industry perspective on the commitment across the industry to implement strategies for durable GE crop deployment based on effective insect resistance management (IRM). Refuges, “high dose” traits, and pyramiding toxins with multiple modes of action are widely advocated as effective IRM techniques. However, the practice of pyramiding toxins is currently hampered by the narrow range of useful insecticidal proteins. Major companies within the industry are clearly committed to the deployment of durable GE crop technologies that can be reasonably integrated into a farmer’s resistance management program as the basis for stewardship of the technology.