Over the past decade, the U.S. government's flagship global hunger and food security initiative, Feed the Future, has helped over 23 million people escape poverty by promoting agricultural growth, resilience, and nutrition.1 Research and innovation are crucial for achieving these goals; however, widespread impact requires adopting and scaling appropriate technologies. To do so, the United States must facilitate collaboration between centrally-funded Feed the Future Innovation Labs (FTFILs) and field-based U.S. Agency for International Development (USAID) Missions to develop context-specific solutions that meet the needs of the target population. This report takes a case-study approach to examine two successful instances of coordination between USAID Missions and FTFILs. The analysis aims to understand the factors contributing to two successful collaborations and offer insight into increasing the impact and scaling of Feed the Future-funded innovations through strategic engagement between USAID Missions and FTFILs. Presently, there is not an effective strategy for fostering collaboration between FTFILs and USAID Missions, leading to missed opportunities in innovation adoption, scaling, and impact in USAID's Zone of Influence (ZOI). This report recommends (1) encouraging Missions to leverage Innovation Lab expertise through Associate Awards, (2) requiring Mission Implementing Partners to collaborate with Innovation Labs to produce contextually relevant research outputs, and (3) strategically engaging with Missions regarding Innovation Lab research streams.