A 1-year-old neutered male domestic shorthair cat presented for a three-day history of progressive lethargy, inappetence, and labored breathing. Rectal temperature was 104.1F. The patient was tachypneic with increased respiratory effort. Harsh lung sounds were auscultated bilaterally. A moderate volume of heterogeneous free fluid was present in the pleural space on ultrasound. Point of care blood work identified a mixed acid-base disturbance characterized by respiratory alkalosis and metabolic acidosis. Thoracocentesis yielded a large volume of thick, brown, malodorous fluid with pale tan granular material suspended throughout. This fluid was confirmed to be suppurative exudate with filamentous rod-shaped bacteria on cytology. Thoracic radiographs and computed tomography (CT) scan showed the presence of multiple pleural abscesses, pleural empyema, ventral consolidation of all lung lobes, diffuse pleuritis and mediastinitis, and bilateral normotensive pneumothorax. Initial stabilization was performed and bilateral 14-gauge Mila thoracostomy tubes were placed. The patient was hospitalized and maintained on intravenous fluids, antibiotics, and analgesics. Chest tubes were aspirated every four hours, and the chest was lavaged with warm saline twice daily. The patient was sent home with three weeks of oral antibiotics. Three-week follow-up thoracic radiographs were normal, but evidence of lung consolidation and pleural adhesions was present on thoracic ultrasound. The patient made a near-full recovery. This paper discusses one approach to managing a case of feline pyothorax. Pyothorax is a life-threatening, often insidious process for which there is little standardization in treatment and management. This case well illustrates current approaches and challenges to treating and identifying the etiology of pyothorax in cats.