Topics in this Annual Report include: A Message from the Director (Douglas F. Antczak); Infectious Diseases and Immunology (Albert C.Bostwick Laboratory of Molecular Biology, Mucosal Immunity Laboratory, Immunology Laboratory, Hadley C. Stephenson Laboratory for the Study of Canine Diseases, Equine Genetics Center, Twenty Years of Equine Research at the Baker Institute 1978-1998); Genetics and Development (John M. Olin Laboratory for the Study of Canine Bone and Joint Diseases, Laboratory of Cellular Growth and Differentiation, Laboratory for the Study of Inherited Canine Reproductive Diseases, Donnelley Laboratory of Gene Regulation and Expression, Inherited Eye Disease Studies Unit); Vision for the 21st Century; Beyond the Laboratory (Publications; Staff of the Baker Institute; Advisory Council); Acknowledgements.