In this necropsy case study report, a 1 year old, male, Ring-necked pheasant presented for cachexia, lethargy and sudden death. Necropsy findings revealed tan to white, multifocal nodular lesions within the liver, intestines and spleen. Ancillary cultures revealed bacteria that were not responsible for the lesions detected. Ziehl-Neelsen staining of tissue impressions were inconclusive however, staining of fixed tissues, that included the liver and intestines showed significant acid-fast staining bacilli. We compare the presentation and diagnosis of the various differentials of nodule forming diseases. Those included in the comparison are Mycobacterium avium, Hjarre’s Disease (avian pathogenic Escherichia coli), Pullorum Disease (Salmonella enterica serovar pullorum) and Nocardia species.