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  5. Shifting metabolism alters rRNA expression in malaria parasites

Shifting metabolism alters rRNA expression in malaria parasites

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File(s)
41741251.pdf (1.07 MB)
No Access Until
2027-02-24
Permanent Link(s)
https://hdl.handle.net/1813/125157
Collections
Department of Microbiology and Immunology
Author
Hadjimichael, Evi
Deitsch, Kirk W.
Abstract

Malaria parasites display the unique property of expressing distinct ribosomal RNAs at different points in their transmission cycle. Couble et al. determined that derepression of the mosquito-specific rDNA loci is initiated by altered NAD+/nicotinamide (NAM) ratios, resulting from the metabolic shift that parasites undergo as they transition into the mosquito stages.

Journal / Series
Trends in parasitology
Volume & Issue
42(3)
Date Issued
2026-02-24
Publisher
Cell Press
Keywords
WCM Library Coordinated Deposit
•
RNA, Ribosomal/metabolism/genetics
•
Animals
•
Plasmodium/metabolism/genetics
•
Silent Information Regulator 2 (Sir2)
•
glycolysis
•
histone deacetylase
•
oxidative phosphorylation
•
ribosomal RNA
Related DOI
https://doi.org/10.1016/j.pt.2026.01.014
Previously Published as
Hadjimichael E, Deitsch KW. Shifting metabolism alters rRNA expression in malaria parasites. Trends in parasitology. 2026;42(3):158-159. doi: 10.1016/j.pt.2026.01.014. PMID: 41741251.
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Rights URI
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type
article

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