This is a report on the Cornell University Library activities in response to two linked faculty initiatives, the Cornell Genomics Initiative (CGI) and the New Life Sciences Initiative (NLSI). The Cornell University Library has always supported the life sciences, through instruction on the use of Medline and Biosis since before this incoming freshman class was born and through exemplary collections in the life sciences. This report describes how the Library responded to the two University initiatives in the life sciences that began in 1998. In Phase I (CGI) the activity was centered in Mann Library, in Phase II the activity was in transition, in Phase III (NLSI) the library participation expanded to all the science units.