"Cal," an 11 year old, female spayed Collie, presented to the referring veterinarian in spring of 2005 with a two day history of hematuria. She had been on phenylpropanalamine for a history of chronic urinary incontinence. The referring veterinarian performed an in house urinalysis, which revealed many red and white blood cells. A urine culture and sensitivity was sent to the clinical laboratory, Antech, and revealed Staphylococcus intermedius that was sensitive to enrofloxacin. Cal was prescribed a 21 day course of enrofloxacin. The hematuria did not resolve. Cal returned to the referring veterinarian and an abdominal ultrasound was performed. It revealed a 2.2 x 1.7 cm mass on the dorsal bladder wall that extended into the trigone. There was no evidence of metastases to regional lymph nodes or neighboring organs. Small calculi in the renal pelvic recesses were noted bilaterally. These findings were most likely secondary to a previous pyelonephritis. A fine needle aspirate of the bladder mass was obtained and submitted for cytology. Alternative methods of sampling the tumor should be considered when there is a mass in the bladder as there are reports of transitional cell carcinoma (TCC) transplantation following this procedure. The cytology was non-diagnostic and Cal was prescribed the non-steroidal anti-inflammatory drug, Piroxicam, for a presumptive transitional cell carcinoma of the bladder. Call was referred to a private practice with experience in cystoscopy and cytoreduction of transitional cell carcinomas in the lower urinary tract.